Dietary vs. Meso-zeaxanthin

Orange Paprika Pepper

Are dietary zeaxanthin and meso-zeaxanthin the same?

  1. Dietary zeaxanthin and meso-zeaxanthin are different ingredients.

  2. Dietary zeaxanthin contained in EyePromise supplements is derived from orange paprika peppers grown and processed in the USA.

  3. The landmark AREDS 2 clinical research study1 evaluated lutein, dietary zeaxanthin, zinc, omega 3s, vitamin C, E, and copper in 4,203 subjects with intermediate or advanced AMD. Meso-zeaxanthin was not evaluated in this study.

  4. The Zeaxanthin and Visual Function Study2 demonstrated a robust macular pigment optical density increase and visual function improvements following supplementation of 8mgs of dietary zeaxanthin daily for 12 months in elderly subjects.

    Results: β€œIn the zeaxanthin group, detailed high-contrast visual acuity improved by 1.5 lines, Retina Foundation of the Southwest shape discrimination sharpened from 0.97 to 0.57 (P = 0.06, 1- tail), and a larger percentage of zeaxanthin patients experienced clearing of their KVF central scotomas (P = 0.057)”

1. Lutein +Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration The Age-Related Eye Disease Study 2 (AREDS2) Randomized Clinical Trial

Author: Emily Y. Chew, MD, National Eye Institute, National Institutes of Health, Bldg 10, CRC Room 3-2531, 10 Center Dr, MSC 1204, Bethesda, MD 20892-1204 (

JAMA. 2013;309(19):doi:10.1001/jama.2013.4997

2. Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration
The Zeaxanthin and Visual Function Study (ZVF)
FDA IND #78, 973

Stuart P. Richer, O.D., Ph.D.,a,b William Stiles, M.D., J.D.,a Kelly Graham-Hoffman, PsyD,a Marc Levin, M.D., J.D.,a Dennis Ruskin, O.D.,c James Wrobel, DPM,b Dong-Wouk Park,b and Carla Thomasa

aCaptain James A. Lovell Federal Health Care Facility, North Chicago, Illinois; bRosalind Franklin University of Medicine and Science, Chicago Medical School, North Chicago, Illinois; and cPrivate Practice, Toronto, Canada.

Optometry (2011) 82, 667-680

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