EyePromise Science Summary

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Since 2001, EyePromise has been passionate about prevention and dedicated to fighting AMD through science-based nutraceuticals. To date, more than 300 published studies exist on nutrition, macular pigment, and the impact on eye health.

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AMD & Macular Pigments:

(Zeaxanthin and Lutein)

AREDS 2 Study

(Chew, MD. et. al.)

• The AREDS 1 formula plus Lutein & Zeaxanthin vs. AREDS 1 & beta-carotene:

– 18% reduction in the progression to advanced AMD

– 22% reduction in the risk of progression to neovascular AMD

• AREDS formula along with Lutein + Zeaxanthin vs. AREDS formula with no Lutein + Zeaxanthin:

– 10% additional reduction in the risk of progression to advanced AMD

– 11% reduction in the risk of progression to neovascular AMD

– 26% reduction to advanced AMD in the lowest quintile – the group with the lowest dietary intake of Lutein and Zeaxanthin, which is more representative of the general population

Improvement of Retinal Function in Early Age-Related Macular Degeneration After Lutein and Zeaxanthin Supplementation: A Randomized, Double-Masked, Placebo-Controlled Trial

(Ma et. al. – American Journal of Ophthalmology, October 2012, Peking University Eye Center, Beijing, China)

• 108 subjects with early AMD supplemented with 10mg Lutein, 10mg Lutein & 10mg Zeaxanthin, 20mg Lutein, or placebo plus 36 age matched controls. (144 subjects)

• Pre and post supplementation multi-focal ERG was measured in 6 concentric annular zones around the macula

• Increased MPOD related positively to increases in N1P1 response density in ring 1 and ring 2 with little effect in ring 3 thru 6

• Improvement of N1P1 response densities was positively associated with MPOD increase, suggesting a causative effect of MPOD on retinal function and health

• Early functional abnormalities of the central retina in the early AMD patients may be improved by Lutein and Zeaxanthin supplementation

• The 10mg Lutein/10mg dietary Zeaxanthin arm had the greatest ERG documented retinal function increase in ring 1.