Macular Health



EyePromise Restore Macular Health Formula

EyePromise Restore replicates the natural 2:1 ratio of zeaxanthin to lutein found in a healthy fovea to help rebuild macular pigment, preserve and enhance healthy vision, and fight against Age-related Macular Degeneration (AMD).


  • Highest level of dietary zeaxanthin available
  • Macular health formula designed to be taken with a multi-vitamin
  • The only brand guaranteed to increase Macular Pigment Optical Density (MPOD)
  • Highest-quality, natural ingredients
  • Manufactured in the U.S.A.

EyePromise macular pigment formulas are designed to increase macular pigment, providing vision protection and enhancement. Low macular pigment is a leading risk factor for AMD, which is the leading cause of severe vision loss in adults over the age of 55, affecting millions of Americans each year. The leading risk factors for AMD and visual performance challenges include:


Non-Modifiable & Modifiable

  • Age
  • Family history
  • Light skin and eyes
  • Female gender
  • Smoking
  • Poor diet
  • Low macular pigment
  • High Body Mass Index (BMI)
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Visual Performance Challenges

  • Night driving difficulty
  • Discomfort due to glare (day or night)
  • Sensitivity to bright light
  • Difficulty seeing objects against their background (contrast sensitivity)
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EyePromise Restore is formulated for:

  • Patients with AMD risk factors
  • Low MPOD
  • Improved visual performance

EyePromise Retstore Nutrition Fact Panel


Considered one of the leading companies in ocular nutrition, EyePromise places the highest priority on product quality. Our nutraceuticals are pharmaceutical-grade, contain the highest-quality ingredients, and are manufactured to the exacting standards of the FDA current Good Manufacturing Practice (cGMP) requirements.

Benefits of EyePromise Nutraceuticals:

Manufactured in the U.S.A.
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EyePromise® Restore Supplements

What benefits can a patient expect by increasing their macular pigment density?

Results may be patient dependent, however many patients report reduced sensitivity to bright light or photophobia, increased contrast sensitivity, increased color saturation, improved fine detail discrimination, improved night vision and night driving, better visual acuity, and better dark adaptation. Healthy macular pigment level has also been scientifically demonstrated to reduce risk of age-related eye disease.

How does ZeaVision® ensure EyePromise quality?

EyePromise is manufactured to the FDA government cGMP (current Good Manufacturing Practice) standard to ensure the highest quality production standards. All ingredients are evaluated for purity, composition, strength, and quality. Testing occurs before, during, and after manufacturing. ZeaVision also conducts third party analysis of finished product to ensure EyePromise content is consistent with product labeling.

What makes the EyePromise supplement unique vs. others in the market?

The level of dietary zeaxanthin in EyePromise is patent protected and the highest level available. The zeaxanthin in EyePromise is a natural form of dietary zeaxanthin. Zeaxanthin is less common in the average diet than lutein and EyePromise is uniquely designed to fulfill this important need. EyePromise has the right mix of ingredients scientifically demonstrated to be essential for healthy vision.

How does each EyePromise ingredient benefit the eye?

Vitamins C and E are powerful antioxidants; Omega-3 is an important constituent of the retina modulating inflammatory processes; Zinc is involved in enzyme catalytic function and metabolism; Zeaxanthin is a superior photo-protectant and antioxidant; Lutein is also a photo-protectant and antioxidant and Alpha Lipoic Acid is another powerful antioxidant that recycles vitamins C and E.

When should a consumer take EyePromise Zeaxanthin. vs. EyePromise Restore?

If the consumer is allergic to shellfish or seafood or they are taking a large number of other vitamins contained in EyePromise Restore, a zeaxanthin-only supplement may be preferred. For instance, if one is taking an eye supplement with a low level of zeaxanthin or no zeaxanthin, adding EyePromise Zeaxanthin to one’s daily supplement regimen may be desirable.

Why doesn’t EyePromise Restore contain copper?

The original AREDS formula contains a high level of zinc (80mg zinc oxide). At this zinc level, copper must be added to a supplement formulation to minimize the risk of copper deficient anemia. This is the reason copper was added to the original AREDS formulation. The AREDS II formulation contains a reduced zinc level of 25mg because of the original AREDS study findings. EyePromise Restore contains only 15mg of zinc per softgel to mitigate these concerns, and is safe to take with a multi-vitamin containing zinc. The recommended upper daily level of zinc is 40 mg.

Why isn’t EyePromise available in retail stores?

ZeaVision sells EyePromise in the professional channel where EyeCare Professionals can properly explain the benefits of specific supplement ingredients and proper quantity to maintain healthy vision. Retail stores typically sell a confusing array of eye supplements and it’s often very difficult to identify important differences between products.


EyePromise Restore Dosing

1. How can I help patients remember to take EyePromise?

First, by demonstrating on successive MPOD testing that their macular pigment has increased. With use of the QuantifEye® MPS II device, the benefit of taking a supplement can be demonstrated. EyeCare Professionals should contact patients shortly after their initial visit to determine whether the patient is complying with your supplement recommendation. This will also allow the EyeCare Professional to assess whether the patient has experienced any functional improvements such as reduction of photophobia, improved glare recovery and night driving, contrast improvement, increased color saturation, night vision, dark adaptation or going from a lighted room into a dark room. Any positive experience reinforces supplement compliance.

2. When should patients take EyePromise?

EyePromise supplements should be taken with a meal, preferably a meal that contains at least a small amount of fat, such as a piece of buttered toast.

What is the maximum dose of zeaxanthin a patient can safely consume per day?

Although the safety of much higher daily doses has been documented, ZeaVision only recommends the dosage listed on the supplement fact panel. The Joint Expert Committee on Food Additives (JECFA), the scientific advisory body to the Codex Alimentarius Commission, has set the acceptable daily intake for the antioxidant ingredients, alone or in combination, at up to 2 mg per kilogram of body weight. This means for a 160lb./72.6 kg person, approximately 145 mg of lutein/zeaxanthin would be considered safe.

Can patients take EyePromise with a multi-vitamin?

Yes, EyePromise Restore is scientifically formulated with that in mind and it is recommended that the patient take a multi-vitamin each day along with EyePromise.

Should children and young adults take EyePromise?

Consult with your Eyecare and family doctor regarding consumption of EyePromise if under the age of 18. It is believed much of the eye damage that manifests late in life occurs during our younger years. Mounting evidence also suggests that consuming zeaxanthin may provide functional improvements. Some patients report these improvements within six months of beginning EyePromise supplementation. Improvements such as reduced light sensitivity, increased contrast sensitivity with more saturated colors, improved night driving, and overall night vision are reported. Adults should follow the dosage recommendation provided on the label.

Why does EyePromise contain only 250 mg of fish oil?

250 mg of fish oil per day is consistent with 2 servings of cold water fish consumption per week – the recommended weekly dietary intake. All EyePromise ingredients are the highest available quality. In spite of the associated cost related to high quality, ZeaVision is focused on minimizing per serving cost to consumers while providing a formulation that delivers optimal eye protection. Additionally, adding more fish oil would increase the number of softgels required daily and significantly increase the size of the softgel, both of which are undesirable. In general, ZeaVision agrees more Omega-3s would be healthy; however, ZeaVision balanced consumer cost, softgel size, and required softgel servings per day to meet the needs of the majority of consumers. EyePromise is scientifically formulated with the right ingredients and dosage to provide optimal eye health benefits, at a low cost.

7. How long will patients need to take EyePromise supplements?

To maintain your macular pigment level after you reach the desired level, you must continue to take EyePromise. Once you achieve the target level, your doctor may lower your prescription to one softgel per day if you were taking two softgels. If you stop taking EyePromise your macular pigment level will return to your baseline level over time. Additionally, you should make the lifestyle changes your doctor recommends to receive the maximum benefit of EyePromise.


Zeaxanthin and Lutein

Some patients have high macular pigment scores after taking lutein supplements. Is lutein the only carotenoid needed to protect healthy vision?

The macula contains both lutein and zeaxanthin and the eye preferentially accumulates zeaxanthin in the center of the macula where the highest density of visual cells reside. Supplementing with lutein will increase macular pigment; however, the most crucial area of the macula may have deficient protection without zeaxanthin and recent science demonstrates unique differences between the two carotenoids.

Has zeaxanthin safety been reviewed by the FDA?

The FDA does not approve vitamins and supplements. Three zeaxanthin safety studies have been conducted and submitted to the FDA and approval obtained. ZeaVision takes safety and quality very seriously.

Why does EyePromise contain 4mg of lutein vs. the 10mg dose in the AREDS II formula?

The decision to incorporate a 2:1 zeaxanthin to lutein ratio in EyePromise is based on the actual ratio in the center of the macula rather than the AREDS II formulation which contains a dietary ratio of 5:1 lutein to zeaxanthin. Although lutein is more readily available than zeaxanthin in the diet, the eye still chooses to place a 2:1 ratio of zeaxanthin to lutein in the center of the macula, the area with the highest concentration of visual cells.

How do zeaxanthin and lutein differ? Are there benefits to taking both?

Zeaxanthin and lutein are molecularly similar however they each orient themselves differently in the cell with zeaxanthin having two ends reactive for antioxidant activity, and lutein only one. The deposition of these antioxidants in the eye varies as zeaxanthin is in higher concentration in the cone-rich center of the macula and lutein is in higher concentration in the peripheral area of the macula. The eye preferentially deposits zeaxanthin in the fovea, suggesting a distinct and different role for each.

What is the difference between meso-zeaxanthin and zeaxanthin?

Meso-zeaxanthin is a stereoisomeric form that is ONLY found in the macula of the eye. It is not found in the blood stream, other organs, or food supply. Human safety data on meso-zeaxanthin has not been submitted to the FDA. Meso-zeaxanthin is not in the food chain. Some indicate meso-zeaxanthin is found in the skin of an Asian fish, or in the carapace (shell) of a crustacean, but not in the food supply. Since human safety studies have not been conducted, long term effects of ingesting meso-zeaxanthin are unknown. Furthermore, marketed meso-zeaxanthin is synthesized by a harsh chemical treatment of lutein, thus meso-zeaxanthin is synthetic.

What zeaxanthin and lutein source does ZeaVision utilize in EyePromise supplements?

Both carotenoids provided in EyePromise are derived from natural sources. The lutein utilized in EyePromise is derived from marigolds and the zeaxanthin is derived from red paprika peppers. Meso-zeaxanthin is not natural.

Why does EyePromise Restore not contain meso-zeaxanthin?

Meso-zeaxanthin is not in the food supply, nor is it found in human blood or organs. All marketed supplements containing meso-zeaxanthin contain synthetic meso-zeaxanthin, created by a harsh chemical treatment of lutein. The long-term effect of ingesting meso-zeaxanthin is not known. Meso-zeaxanthin is only found in the macula of the eye and it is theorized that meso-zeaxanthin it is created by lutein conversion into this intermediate molecule. It is hypothesized that meso-zeaxanthin is created when the eye doesn’t obtain adequate dietary zeaxanthin. No meso-zeaxanthin human safety studies have been filed with the FDA.


QuantifEye Device

Is the QuantifEye MPOD measurement repeatable and reproducible?

Yes, the technology has been scientifically validated in multiple clinical studies. As the exam is “psychophysical”, there may be very slight variances from test to test, however measurement results should not vary more than .05 on average. More importantly, the software generates a graph for each patient so the operator knows if the patient understands the exam and is responding to the target appropriately. This is vital to achieving accurate results and the QuantifEye device is unique in this regard. It is important to position the device in the practice where there will be minimal distractions while the patient is taking the exam. The operator should also remind the patient to blink frequently during the exam.

What does it mean if a patient’s graph line goes up or down at a 45 degree angle?

If the graph line goes up at or near a 45 degree angle, this generally indicates that the patient has extremely low macular pigment and their starting point is the minimum value because they have little or no absorption of blue light (very rare). Test again to see if this is repeated. If the same result is obtained, the patient should be prescribed two EyePromise Restore softgels per day and return for re-measurement in six months. Adequate pigment build should occur during this time to achieve a reading. 

For the graph line that trends down at or near a 45 degree angle and never turns up, this generally means the patient has very high macular pigment. The test may time out, as the graph never turns up to form three consecutive points up. Repeat the test and ask the patient to enhance their concentration to obtain a result. If a measurement cannot be achieved (very rare), an assumption of high macular pigment should be made. The patient may or may not need EyePromise supplementation dependent upon other AMD risk factors and their retinal exam.


Macular Pigment Measurement

What macular pigment density measurement is considered low? Mid-range? High?

Data collected from clinical studies and QuantifEye devices suggests a macular pigment density level below .25 is low, .26 to .50 is the defined mid-range, and a macular pigment density of .50 and above is high.

How often should patients have their macular pigment measured?

The patient should visit their eye care professional to obtain a baseline macular pigment level reading and repeat the measurement every six months until the macular pigment level reaches .50. After the patient’s macular pigment level reaches the target level, the eye care professional will recommend continued EyePromise supplementation to maintain a healthy level, and schedule future measurements based on individual patient needs.

When will patients start to notice change based on improved macular pigment?

Patients with low macular pigment will generally begin to notice positive changes after initiation of supplementation with EyePromise after 3 to 6 months. Measureable macular pigment improvement can be obtained at 6 months, if the patient has been compliant taking EyePromise Restore.

What is the desired macular pigment density level?

The macular pigment scale is 0 to 1. The macular pigment density average in the U.S. population is .34. Approximately 43% of the U.S. population is reported to have low macular pigment, meaning they are below the U.S. average. Based on extensive data collection, .50 is the desired target level as this is the high end of the mid-range and low end of the top tertile. Data suggests that 80% of the U.S. population is below the preferred macular pigment level of .50. The ever increasing diagnosis and prevalence of Age Related Macular Degeneration (AMD) suggests that the U.S. macular pigment average is not adequately protecting eyes. It is estimated that 15-million Americans have some degree of AMD.

What is the average macular pigment increase after 6 months of EyePromise Restore consumption?

Data demonstrates an average macular pigment increase of 54% after 6-months of EyePromise Restore ingestion.


Prior to Measuring Patients

What should I do if a patient has a “Yellow-Tinted” intraocular lens implant (i.e. AcrySof, Alcon Laboratories) and wants to take the QuantifEye exam?

If the intraocular lens implant is one of the “yellow” lens used for protection against UV light, a peripheral reading must be performed to obtain an accurate reading, as the yellow in the lens will be additive to the macular pigment.

What should I do if a patient has a clear intraocular lens implant?

Perform a peripheral measurement in addition to the central measurement or set the patient’s age at 21 years in the software program. Setting the patient’s age at 21 years of age in the software program is the preferred approach as a central measurement will suffice.

What should I do if the patient wears tinted contact lenses and wants their MPOD measured?

Any contact lens that has more than “handling tint” needs to be removed before the exam. Handling tint does not affect exam accuracy and the patient may wear their contact lenses. However, if the patient has cosmetically tinted contacts, they need to be removed prior to the evaluation.

What should I tell patients taking the QuantifEye exam about wearing vision correction?

Patients may wear their correction or not, whatever feels the most comfortable for them. In most cases, the patient will feel more comfortable when they can see clearly, whether with or without correction. Colored lenses (contacts or glasses) beyond handling tint for contacts need to be removed.

Which patients should have a peripheral MPOD measurement vs. central only?

A patient should take a peripheral and central measurement when a visible cataract exists or has a “yellow” intraocular lens implant or the patient is aphakic, having no lens or in the case of the “yellow” intraocular implant.

How does QuantifEye MPOD data correlate to carotenoid skin measurement?

A marketed device measures carotenoid level in the skin and scientists have attempted to correlate data obtained from the device to increased macular pigment. However, since the device measures carotenoid accumulation in the skin beyond the eye pigments zeaxanthin and lutein, studies have not demonstrated a useful correlation to what is occurring in the eye. Zeaxanthin and lutein accumulate in the skin; however, the amount of skin deposition is dependent upon the amount of adipose tissue (fat) in an individual patient. Science has demonstrated zeaxanthin accumulation in the skin and increased SPF and this may provide important skin protection for those regularly exposed to sun exposure.


QuantifEye Software

How does the QuantifEye device software allow for age-related yellowing of the lens?

When doing a central only reading with the estimate, the software contains a formula based on data obtained from thousands of cases and is a linear progression of yellowing dependent upon age (older = more yellowing.) Clinical confirmation of using the estimate versus doing the peripheral has validated the accuracy of utilizing the software estimate.

How can I back up MPOD patient data on the laptop? How often should I do so?

ZeaVision provides a USB flash drive with every QuantifEye device that contains two programs: One to back up patient data and one to restore the data to the laptop when/if needed. Back up of data should occur on a frequent basis. It is recommended to back up data at the end of each day or first thing each morning to minimize the risk of losing data.

How can I transfer a patient’s MPOD data into our EMR system?

At the present there is no means of transferring data directly from the device to an EMR program. Depending upon the EMR system employed, one option is to take a screen shot of the graph and data as a jpeg file and save them electronically. At this point one can transfer the data to the patient’s record in the EMR system.



What are the primary and secondary risk factors associated with Age-related Macular Degeneration (AMD)?

The primary AMD risk factors are age, genetic pre-disposition or family history, smoking, and low macular pigment. Secondary risk factors are female gender, light colored skin and eyes, high body mass index, unprotected exposure to the sun, and poor diet. Some risk factors are modifiable and some are not. Increasing macular pigment is an important modifiable risk.

What is the relevance and relationship between MPOD and age-related eye disease?

Numerous epidemiological and clinical studies reflect the overwhelming evidence that low macular pigment is a risk factor for Age-related Macular Degeneration. (AMD). Low macular pigment is but one risk factor for AMD and therefore an absolute correlation to a single risk factor cannot be determined. This is analogous to maintaining a healthy cholesterol level. Science has demonstrated that maintaining a healthy cholesterol level correlates to reduced risk of cardiovascular disease and stroke, however managing this single risk factor does not guarantee one will not suffer a heart attack or stroke.


Miscellaneous Questions

Why isn’t EyePromise available in retail stores?

ZeaVision sells EyePromise in the professional channel where EyeCare Professionals can properly explain the benefits of specific supplement ingredients and proper quantity to maintain healthy vision. Retail stores typically sell a confusing array of eye supplements and it’s often very difficult to identify important differences between products

How does the per-serving cost of EyePromise compare with other eye supplements?

EyePromise is one of the most affordable nutraceuticals in the eye supplement category with a per-serving cost of .51 per day. This is particularly compelling when one compares the number and quality of ingredients provided in EyePromise Restore. EyePromise Restore also has the highest available level of natural dietary Zeaxanthin, a very expensive and important ingredient for eye health.

What are the most common adverse events reported with EyePromise?

In more than 40-million consumed doses, there have been no serious adverse reactions reported with EyePromise. The most frequently reported adverse event is nausea. In the strong majority of reported instances of nausea, the supplement was taken on an empty stomach. To date there have been no consistent or serious adverse events reported following EyePromise consumption. Report any adverse events to ZeaVision (1-866-833-2800), so they can be properly catalogued and followed-up.

. What is the EyePromise supplement shelf life?

The shelf life of EyePromise is two years from date of manufacture.

Can patients take EyePromise if they’re taking Plavix® or Coumadin®?

It is recommended that patients, on a blood thinner, confer with their doctor before starting any vitamin or supplement regimen. EyePromise has insignificant effect on blood thinners at the recommended dosage. Confusion occurs because zeaxanthin and lutein are found in leafy green vegetables and doctors often tell patients taking blood thinners not to eat them. Leafy green vegetables contain Vitamin K, a contraindication for patients taking blood thinners. EyePromise does not contain Vitamin K. The amount of fish oil or Vitamin E in EyePromise is not at a level to be a concern for patients on blood thinners.